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Medical Device Applications for Collagen
This brochure provides a overview of the numerous collagen-based medical device applications that Collagen Solutions can support.
Medical Grade Soluble Collagen Benefits
This brochure summarizes the numerous soluble collagen applications and the benefits of working with a medical grade, highly purified collagen source. To order, click here.
Off-the-Shelf Collagen Products
This brochure describes all of the standard collagen products that are supplied by Collagen Solutions. To order, click here.
Regenerative Orthopaedic Solutions
This brochure highlights our experience and expertise in the development of orthobiologics, including bovine bone chips, Bone Graft Substitute, collagen scaffolds, decellularized ECM, collagen coatings, collagen particles, dressings & grafts, and flowable matrices.
Safe & Reliable Bovine Pericardium for Medical Devices
This brochure highlights our Quality and Logisitics standards and capabilities of our tissue procurement, processing, and delivery.
3D Gel Formation Protocol
This video demonstrates the steps taken to form a 3D gel using our soluble collagen and titration buffer. To order, click here.
Atelo Soluble Collagen White Paper
This white paper provides atelo collagen specifications, storage requirements, and protocols for use. To order, click here.
Biomaterials to Progress Research to Clinic
This technical highlight summarizes the unique physical properties of collagen and the benefits of using medical grade collagen transition technologies into the clinic. To order, click here.
Bovine Tendon Long Fibre Powder White Paper
This white paper provides collagen specifications, storage requirements, and application details for long fibre milled powder from tendon.
Collagen for Cell Delivery
This review provides an overview of numerous applications where collagen has been investigated as delivery vehicle for cell therapies.
Collagen for Drug Delivery
This review provides an overview collagen carriers for a variety of drug delivery applications.
Exclusive IP position for a Unique Pericardium Biomaterial
This technical highlight summarizes the unique pericardium biomaterial properties and their advantages to percutaneous delivery devices for TAVR, TMVR & other transcatheter cardiovascular therapies.
Fibrillar Collagen White Paper
This white paper provides fibrillar collagen specifications, storage requirements, and protocols for use.
Lyophilized Polymeric Collagen White Paper
This white paper provides collagen specifications, storage requirements, and application details for neutral polymeric powder from tendon.
Support for Bovine Collagen in Medical Devices
This literature review addresses the advantages of using collagen in medical devices and clarifies the perceived risks associated with the use of bovine sources.
A Gel Aspiration-Ejection System for the Controlled Production and Delivery of Injectable Dense Collagen Scaffolds
A gel aspiration-ejection (GAE) system has been developed for the advanced production and delivery of injectable dense collagen (I-DC) gels of unique collagen fibrillar densities (CFDs)....read more
A Methylcellulose and Collagen Based Temperature Responsive Hydrogel Promotes Encapsulated Stem Cell Viability and Proliferation In Vitro
With the number of stem cell-based therapies emerging on the increase, the need for novel and efficient delivery technologies to enable therapies to remain in damaged tissue and exert their therapeutic benefit for extended periods, has become a key requirement for their translation....read more
A Micro-Architecturally Biomimetic Collagen Template for Mesenchymal Condensation Based Cartilage Regeneration
The unique arcade-like orientation of collagen fibers enables cartilage to bear mechanical loads. In this study continuous-length aligned collagen threads were woven to emulate the interdigitated arcade structure of the cartilage....read more
Acellular Hydroxyapatite-Collagen Scaffolds Support Angiogenesis and Osteogenic Gene Expression in an Ectopic Murine Model: Effects of Hydroxyapatite Volume Fraction
Acellular hydroxyapatite (HA) reinforced collagen scaffolds were previously reported to induce angiogenesis and osteogenesis after ectopic implantation but the effect of the HA volume fraction was not investigated....read more
Age Dependent Differences in Collagen Alignment of Glutaraldehyde Fixed Bovine Pericardium
Bovine pericardium is used for heart valve leaflet replacement where the strength and thinness are critical properties. Pericardium from neonatal animals (4–7 days old) is advantageously thinner and is considered as an alternative to that from adult animals....read more
Biologic and Synthetic Grafts in the Reconstruction of Large to Massive Rotator Cuff Tears
Rotator cuff injuries are common in both young and elderly patients. Despite improvements in instrumentation and surgical techniques, the failure rates following tendon reconstruction remain unacceptably high. To improve outcomes, graft patches have been developed to provide mechanical strength and to furnish a scaffold for biologic growth across the delicate tendon-bone junction....read more
Biomaterials with Enhanced Properties and Devices Made Therefrom
Biomaterials with enhanced properties such as improved strength, flexibility, durability and reduced thickness are use ful in the fabrication of biomedical devices, particularly those Subjected to continuous or non-continuous loads where repeated flexibility and long-term durability are required....read more
Biomimetic Scaffold Design for Tendon Tissue Engineering to Enhance Mechanoresponse and Tenogenesis
Tendon disorders are some of the most common musculoskeletal problems. Despite improvements in surgical techniques, revision of tendon tear surgery is significantly high....read more
Bovine Pericardium Based Non-Cross Linked Collagen Matrix for Successful Root Coverage, a Clinical Study in Human
The aim of this study was to clinically assess the capacity of a novel bovine pericardium based, non-cross linked collagen matrix in root coverage. 62 gingival recessions of Miller class I or II were treated. The matrix was adapted underneath a coronal repositioned split thickness flap. Clinical values were assessed at baseline and after six months....read more
Collagen as a Biological Glue for Cell Spraying in Wound Healing
In the US, about 6.5 million patients are treated for chronic wounds and burns, with a yearly financial burden of over $25 billion dollars. Worldwide, burns result in 265,000 deaths per year. Currently, the gold standard for wound therapy is the use of either split- or full-thickness autologous skin grafts....read more
Collagen Fibril Strain, Recruitment and Orientation for Pericardium Under Tension and the Effect of Cross Links
The structural response of collagen fibrils in pericardium and other tissues when subjected to strain and the effect of cross linking on those structural changes are not well understood. Specifically, there is uncertainty about whether natural cross links of glycosaminoglycan (GAG) and synthetic cross links of glutaraldehyde have a mechanical function....read more
Collagen Substrate Stiffness Anisotropy Affects Cellular Elongation, Nuclear Shape, and Stem Cell Fate Toward Anisotropic Tissue Lineage
Rigidity of substrates plays an important role in stem cell fate. Studies are commonly carried out on isotropically stiff substrate or substrates with unidirectional stiffness gradients....read more
Cross Linking and Fibril Alignment in Pericardium
The influence of natural cross linking by glycosaminoglycan (GAG) on the structure of collagen in animal tissue is not well understood. Neither is the effect of synthetic cross linking on collagen structure well understood in glutaraldehyde treated collagenous tissue for medical implants and commercial leather....read more
Delivery of the Improved BMP-2-Advanced Plasmid DNA Within a Gene-Activated Scaffold Accelerates Mesenchymal Stem Cell Osteogenesis and Critical Size Defect Repair
Gene-activated scaffolds have been shown to induce controlled, sustained release of functional transgene both in vitro and in vivo. Bone morphogenetic proteins (BMPs) are potent mediators of osteogenesis however we found that the delivery of plasmid BMP-2 (pBMP-2) alone was not sufficient to enhance bone formation....read more
Ectopic Bone Formation in Rapidly Fabricated Acellular Injectable Dense Collagen-Bioglass Hybrid Scaffolds via Gel Aspiration-Ejection
Gel aspiration-ejection (GAE) has recently been introduced as an effective technique for the rapid production of injectable dense collagen (IDC) gel scaffolds with tunable collagen fibrillar densities (CFDs) and microstructures...read more
Effect of Actuating Cell Source on Locomotion of Organic Living Machines with Electrocompacted Collagen Skeletons
In robotics, there is a need for small scale, compliant actuators for use in medical applications or minimally invasive environmental monitoring. Biohybrid devices offer one solution to this need by using muscle cells to actuate compliant scaffolds....read more
Effects of Substrate Stiffness on the Tenoinduction of Human Mesenchymal Stem Cells
Extracellular matrix modulus plays an important role in regulating cell morphology, proliferation and differentiation during regular and diseased states....read more
Electrospin Silk-Collagen Scaffolds and BMP-14 for Ligament and Tendon Repair and Regeneration
Regenerative ligament and tendon repair scaffolds have been highly researched, yet few match the mechanical properties of native tissue, while fewer drugs have been explored for enhancing cell infiltration into the damaged tissu...read more
Evaluation of a Collagen-Coated, Resporbable Fiber Scaffold Loaded with a Peptide Basic Fibroblast Growth Factor Mimetic in a Sheep Model of Rotator Cuff Repair
A new scaffold design combined with a peptide growth factor was tested prospectively for safety and for improved tendon healing in sheep. The infraspinatus tendon was detached and then surgically repaired to the humerus using sutures and anchors in 50 adult sheep....read more
Evaluation of Fibroblast Behavior on a Collagen-Based Spray Adhesive
The ongoing search for a suitable surgical adhesive is fueled by deficiencies of current products such as mechanical properties, bonding strengths and curing times. An adhesive in a sprayable form has much appeal for ease of application. Collagen has shown great potential as an adhesive for its biocompatibility, blood absorption and hemostatic properties1....read more
Evaluation of the Immunomodulatory Effects of All-Trans Retinoic Acid Solid Lipid Nanoparticles and Human Mesenchymal Stem Cells in an A549 Epithelial Cell Line Model
To investigate two potential strategies aimed at targeting the inflammatory pathogenesis of COPD: a small molecule, all trans retinoic acid (atRA) and human mesenchymal stem cells (hMSCs).
Flow Simulation of a Natural Polymer in a Syringe-Needle Delivery Device
Neurodegenerative diseases, such as Parkinson’s disease, affect a large number of the erderly population and still remain untreated. In recent years, cell therapy has emerged as a promising therapeutic strategy. To increase cell viability, biomaterials are often used as scaffolds and facilitate cell deposition, through injection, to the site of interest....read more
Formulation of Poly(Ethylene Glycol) Hydrogens for Drug Delivery
Although described as a “bioinert” drug delivery platform, PEG hydrogels can also incorporate bioactive materials, such as extracellular matrix amino acid motifs or macromolecules such as collagen....read more
Heparinized Collagen Sutures for Sustained Delivery of PDGF-BB: Delivery Profile and Effects on Tendon-Derived Cells In-Vitro
Suturing is the standard of repair for lacerated flexor tendons. Past studies focused on delivering growth factors to the repair site by incorporating growth factors to nylon sutures which are commonly used in the repair procedure. However, conjugation of growth factors to nylon or other synthetic sutures is not straightforward....read more
Immediate Production of a Tubular Dense Collagen Construct with Bioinspired Mechanical Properties
The intrinsic complexity of tissues and organs demands tissue engineering approaches that extend beyond planar constructs currently in clinical use. However, the engineering of cylindrical or tubular tissue constructs with a hollow lumen presents significant challenges arising from geometrical and architectural considerations required to tailor biomaterials for tissue and organ repair....read more
Influence of Telopeptides on the Structural and Physical Properties of Polymeric and Monomeric Acid-Soluble Type I Collagen
<p>Currently two factors hinder the use of collagen as building block of regenerative devices: the limited mechanical strength in aqueous environment, and potential antigenicity. Polymeric collagen is naturally found in the cross-linked state and is mechanically tougher than the monomeric, acid-soluble collagen ex vivo....read more
Labeling of Collagen Type I Templates with a Naturally Derived Contrast Agent for Noninvasive MR Imaging in Soft Tissue Engineering
In vivo monitoring of tissue‐engineered constructs is important to assess their integrity, remodeling, and degradation. However, this is challenging when the contrast with neighboring tissues is low, necessitating labeling with contrast agents (CAs), but current CAs have limitations (i.e., toxicity, negative contrast, label instability, and/or inappropriate size)....read more
Nerve Growth Factor Released from Collagen Scaffolds Protects Axotomized Cholinergic Neurons of the Basal Nucleus of Meynert in Organotypic Brain Slices
Background: Alzheimer´s disease is accompanied by cell death of cholinergic neurons, resulting in cognitive impairment and memory loss. Nerve growth factor (NGF) is the most potent protein to support survival of cholinergic neurons....read more
On-Demand Release of Hydrosoluble Drugs from a Paramagnetic Porous Collagen-Based Scaffold
The design of a collagen scaffold containing iron oxide nanostructures capped by a TiO2 (anatase) layer is reported....read more
Pneumatospinning of Collagen Microfibers from Benign Solvents
Introduction. Current collagen fiber manufacturing methods for biomedical applications, such as electrospinning and extrusion, have had limited success in clinical translation, partially due to scalability, cost, and complexity challenges....read more
Protease-Sensitive Atelocollagen Hydrogels Promote Healing in a Diabetic Wound Model
The design of exudate-managing wound dressings is an established route to accelerated healing, although such design remains a challenge from material and manufacturing standpoints....read more
Repair of Large Osteochondritis Dissecans Lesions Using a Novel Multilayered Tissue Engineered Construct in an Equine Athlete
Osteochondral lesions resulting from osteochondritis dissecans are problematic to treat and present a significant challenge for clinicians....read more
Scaffold Design for Artificial Tissue With Bone Marrow Stem Cells
Objective: The aim of this study was to test polymeric materials (collagen, fibrin, polyimide film, and polylactic acid) for single- and multi-layer scaffold formation....read more
Structurally Graduated Collagen Scaffolds Applied to the Ex Vivo Generation of Platelets from Human Pluripotent Stem Cell-Derived Megakaryocytes: Enhancing Production and Purity
Platelet transfusions are a key treatment option for a range of life threatening conditions including cancer, chemotherapy and surgery. Efficient ex vivo systems to generate donor independent platelets in clinically relevant numbers could provide a useful substitute....read more
Supercritical Carbon Dioxide Decellularized Pericardium: Mechanical and Structural Characterization for Applications in Cardio-Thoracic Surgery
Introduction: Many biomaterials are used in cardio-thoracic surgery with good short-term results. However, calcification, dehiscence, and formation of scar tissue are reported. The aim of this research is to characterise decellularised pericardium after supercritical carbon dioxide (scCO2) processing as an alternative biological material for uses in cardio-thoracic surgery....read more
Synthesis and Fabrication of Nanocomposite Fibers of Collagen-Cellulose Nanocrystals by Coelectrocompaction
An electrochemical process has been used to compact cellulose nanocrystals (CNC) and access aligned micron-sized CNC fib...read more
The Effect of Different Collagen Modifications for Titanium and Titanium Nitrite Surfaces on Functions of Gingival Fibroblasts
Targeted modifications of the bulk implant surfaces using bioactive agents provide a promising tool for improvement of the long-term bony and soft tissue integration of dental implants....read more
Therapeutic Efficacy of Glial Cell-Derived Neurotrophic Factor Loaded Collagen Scaffolds in Ex Vivo Organotypic Brain Slice Parkinson's Disease Models
Glial cell line-derived neurotrophic factor (GDNF) is a potent trophic factor that supports the survival of dopaminergic neurons of the substantia nigra (SN), which degenerate in Parkinson’s disease (PD). The application of GDNF to the brain is challenging but biomaterials such as collagen can present novel strategies to target therapeutics to the brain....read more
Towards an Effective, Needle-Based Delivery Device for Parkinson's Disease: A Simulation Study on the Impact of Needle Diameter
Recently, several therapies have emerged for Parkinson’s disease, a challenging neurodegenerative disorder. However, clinical translation is restricted, partially due to limitations in delivering therapeutics to the Central Nervous System (CNS) which cannot be reached by systemic administration....read more
Translating the Role of Osteogenic-Angiogenic Coupling in Bone Formation: Highly Efficient Chitosan-pDNA Activated Scaffolds Can Accelerate Bone Regeneration in Critical-Sized Bone Defects
The clinical translation of bioactive scaffolds for the treatment of large segmental bone defects has remained a challenge due to safety and efficacy concerns as well as prohibitive costs....read more