Why Use Collagen Biomaterials for Regenerative Medicine?

Collagen-based biomaterials have a large range of applications both in vivo and in vitro. Excellent biocompatibility due to weak antigenicity and safety due to biodegradability, makes collagen a primary resource in medical applications. With our comprehensive portfolio of collagen biomaterials and extensive technical expertise, we will decrease your costs and time to market.

Collagen Uses	Collagen Application
Orthopaedic & Sports Medicine	Bone graft substitutes Cartilage repair Tendon repair
Dental	Bone graft substitutes Dental membranes Dental plugs
Wound Care	Collagen dressings and powder Flowable Scaffolds Skin substitutes Wound and burn grafts
Cardiovascular	Vascular grafts Vascular closure devices
General, Plastic & Reconstructive Surgery	Dermal fillers Suture line reinforcement Hernia repair Breast reconstruction
Other	Dural Ophthalmic Oncology

	Bone Graft Substitutes Bioceramics, such as beta tricalcium phosphate and hydroxyapatite, bioactive glass, and other osteoconductive materials are used in the repair and regeneration of bone defects that have developed from disease or due to trauma. The addition of collagen to these materials dramatically improves the handling properties of the bone void filler and encourages cell ingrowth that is needed for tissue regeneration. Collagen Solutions has experience developing synthetic bone graft substitutes for a number of applications, including spine, extremities, and dental.
	Cartilage Repair Collagen scaffolds can be designed to mimic and regenerate native tissues and are being increasingly used in cartilage repair. The pore structure and degradation rate of these scaffolds can be engineered to promote hyaline cartilage regeneration. These scaffolds can be used in cell-free or as a substrate for cell-based therapies.
	Tendon Repair Resorbable membranes and wraps have been shown to protect underlying tissues in the case of tendon trauma. Decellularized ECM or engineering collagen tendon wraps are excellent materials for the repair of soft tissue, such as of rotator cuffs, patellar tendons, Achilles tendon, biceps, quadriceps, and more. Collagen formulations can also be used to coat synthetic tendons and ligaments to enhance cell recruitment and vascularization.
	Dental Membranes These devices are used in dental applications to guide soft tissue regeneration and inhibit the rapid regrowth of skin when implanting bone which takes longer to regenerate. Collagen Solutions has experience supplying raw materials for and manufacturing dental membranes using processed collagen or decellularized tissues.
	Collagen Wound Dressings Collagen is naturally involved in all phases of the wound-healing cascade and the use of collagen-based wound dressings provides several benefits for acute and chronic wound closure. Additionally, collagen dressings can be designed to control the moisture of the wound bed, by either providing or absorbing moisture. Collagen Solutions has experience developing dressings, particles, and flowable scaffolds for the treatment of acute and chronic wounds.
	Skin Substitutes In cases of extensive skin loss, such as severe trauma or burns, skin grafts have several limitations, including the lack of availability of donor tissue. As an alternative, skin substitutes have been developed to replace skin defects using engineered materials. Acellular skin substitutes can be manufactured from decellularized ECM and can be used alone or in combination with other materials, such as glycosaminoglycans or silicon membranes. Collagen scaffolds can also be used with cells in tissue engineered grafts. In this case, the collagen acts as a substrate for the delivery of cells such as keratinocytes and fibroblasts.
	Dermal Fillers Soft tissue fillers are injected directly into the skin to minimize the appearance of wrinkles by physically plumping the skin. Collagen dermal fillers stimulate the body’s natural production of collagen and the scaffold will be replaced with native collagen within months.
	Vascular Closure Devices Vascular closure devices provide immediate sealing of arterial punctures and are an alternative to manual compression. An intravascular anchor is secured to a collagen plug on the outside of the artery to plug the puncture and promote hemostasis.
	Others Collagen Solutions has experience providing raw materials and developing products for numerous other applications, including dural grafts, nerve tubes, ophthalmic shields, tear duct plugs, and more.